Best peptides for weight loss

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Peptides are creating a buzz in the world of weight loss. Aside from giving the body a boost in burning fat, peptides can also assist in gaining muscle mass. So what are peptides? They are made up of amino acids, the same building blocks that make up protein, however peptides are the simple cousins. They are made up of less amino acids than protein, generally about 2-50 amino acids compared with proteins which are normally made up of more than 100 amino acids. 

Research into peptide and their health benefits is in its infancy relatively speaking. Bioactive peptides have been used to treat type-2 diabetes and obesity, but due to limitations such as their stability, size and fast rate of degradation, scientists had not looked much further, until now. 

The spotlight is back on peptides and with advances in technology, it seems peptides may be used more and more for a wide variety of conditions. 

So what do we know about peptides?

Though there isn’t a great deal of research on peptides, particularly in vivo, meaning on real life subjects, we know that they’re great for things like:

  • Weight loss
  • Skin conditions
  • Immune function
  • Hair growth
  • Bone and joint health and the list goes on.

But you’re here to learn more about peptides for weight loss. Got your back. 

Researchers state that there is already interest in using peptides to treat obesity, however further research and work is needed before a therapeutic drug is found.

Peptide supplements are currently in use (via injection mostly) and some are seen as more experimental than others, says Dr Tracy Gapin. It’s important to note that peptides are not approved or regulated by the FDA.

Most common peptides for weight loss


CJC 1295 os a synthetic Growth Hormone Releasing Hormone (GHRH) which means that this peptide encourages the body to release natural Growth Hormone (GH). So many acronyms, I know. Anyway, GR plays a big part in fat breakdown, muscle building, sleep and immune function and blood sugar regulation. Research carried out on the peptide showed that CJC-1295  did indeed raise GH levels and that it was safe and relatively well tolerated, particularly at doses of 30 or 60 microg/kg. Dr Gapin reports that there is scientific evidence to show that CJC 1295 also promotes deep sleep which in turn helps with muscle growth.


This peptide can be combined with others, including CJC-1295 and is a new peptide on the market. Ipamorelin only stimulates Growth Hormone similar to the GHRH. It’s reported to bind to Growth Hormone receptors for longer which makes it more effective. Dr Gapin says that it will increase your hunger so it’s best taken at night. This peptide is known for its anti-aging properties and boosts your energy which is great overall but particularly if you’re exercising as part of a weight loss program. You can take Ipamorelin as a tablet under the tongue which is so much easier than an injection. Ipamorelin is often combined with other peptides for even greater results. 

CJC-1295 and Ipamorelin

According to Amy Brenner, MD and Associates, integrative medicine specialists, the combination of CJC-1295 and Ipamorelin is very effective and has a host of potential benefits in addition to weight loss, including cellular repair and regeneration, collagen production, increased muscle growth and better quality sleep. This combination also inhibits Somatostatin which is a Growth Hormone inhibitor.

Side effects of peptides

You would also need to consider potential side effects for the peptides listed above such as hives, redness at injection side, vivid dreams and flushing. Amy Brenner, MD and Associates also recommend that if you have difficulty sleeping, you should switch to a morning dose, however you should discuss this with your medical practitioner.

Which one is best for you?

All in all, you need to look at what is appropriate for you and your health and also what you are willing to try based on the reported risks. Please remember to take peptides under the supervision of a medical practitioner. Your doctor will be able to recommend the peptide that is best for you. 

Here are some questions to considering ask your doctor when discussing peptides:

  1. Is the peptide safe?
  2. What are the potential side effects?
  3. How is it administered?
  4. Is it FDA approved?
  5. Is there information on the peptide’s efficacy?

For best results, peptide therapy should accompany an exercise and meal plan suitable for weight loss.

It’s important to remember that there are contraindications to these peptides. If you have a history of any form of cancer, these peptides will not be prescribed to you.

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